Fredrik Bajers Vej 5
P.O. Box 159 DK-9100 Aalborg
Phone: +45 9940 9940
Guest lecture on "Descending controls and considerations: a noradrenergic view" by Dr. Kirsty Bannister, Kings College, London.
24.04.2018 kl. 13.00 - 24.04.2018 kl. 14.30
Descending controls comprise pathways that originate in midbrain and brainstem regions and project onto the spinal cord, interacting to produce the overall pain experience. I begin by discussing diffuse noxious inhibitory controls (DNIC), a unique form of endogenous descending inhibitory pathway. Previously we researched the spinal pharmacology of pathways that sub-serve DNIC and showed that, in the normal situation, DNIC produce a final inhibitory effect through the actions of noradrenaline at spinal α2 -adrenoceptors, although serotonin, acting on facilitatory spinal 5-HT3receptors, influences the final expression also.
My current and future research interests remain focused on DNIC and also on mechanisms of gabapentin/pregabalin mediated analgesia. I will highlight our most recent research demonstrating that gabapentin mediated analgesia involves inhibition of injury-induced spinal neuronal excitability and evoked hypersensitivity amongst other factors. My future research interests include understanding precisely what conditioning stimuli can evoke DNIC and whether pregabalin-mediated analgesia at supra-spinal sites interacts with or influences DNIC expression, possibly via spinal 2 adrenoceptor mediated mechanisms.
Fredrik Bajers Vej 7D2, room D2-106