Lecture by Dr. Kirsty Bannister

Guest lecture on "Descending controls and considerations: a noradrenergic view" by Dr. Kirsty Bannister, Kings College, London.


24.04.2018 kl. 13.00 - 24.04.2018 kl. 14.30


See the invitation here.


Descending controls comprise pathways that originate in midbrain and brainstem regions and project onto the spinal cord, interacting to produce the overall pain experience. I begin by discussing diffuse noxious inhibitory controls (DNIC), a unique form of endogenous descending inhibitory pathway. Previously we researched the spinal pharmacology of pathways that sub-serve DNIC and showed that, in the normal situation, DNIC produce a final inhibitory effect through the actions of noradrenaline at spinal α2 -adrenoceptors, although serotonin, acting on facilitatory spinal 5-HT3receptors, influences the final expression also.
My current and future research interests remain focused on DNIC and also on mechanisms of gabapentin/pregabalin mediated analgesia. I will highlight our most recent research demonstrating that gabapentin mediated analgesia involves inhibition of injury-induced spinal neuronal excitability and evoked hypersensitivity amongst other factors. My future research interests include understanding precisely what conditioning stimuli can evoke DNIC and whether pregabalin-mediated analgesia at supra-spinal sites interacts with or influences DNIC expression, possibly via spinal 2 adrenoceptor mediated mechanisms.


Fredrik Bajers Vej 7D2, room D2-106

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