Ph.D. Defense by Peter Skrejborg
Peter Skrejborg will defend his Ph.D. thesis "Prevalence and nature of chronic postsurgical knee pain at patients with total knee replacement"
29.10.2021 kl. 13.00 - 16.00
13.00 Opening by the Moderator Kristian Kjær Petersen
13.05 PhD lecture by Peter Skrejborg
14.00 Questions and comments from the Committee
Questions and comments from the audience at the Moderator’s discretion
16.00 Conclusion of the session by the Moderator
The Faculty Council has appointed the following adjudication committee to evaluate the thesis and the associated lecture:
Dr. Jo Nijs, Vrije Universiteit Brussel, Belgium
Torben Bæk Hansen, Professor, Hospital Unit West, University Clinic for Hand, Hip and Knee Surgery, Holstebro, Denmark
Dr. Jakob Lund Dideriksen, HST, Aalborg Universitet
Dr. Kristian Kjær Petersen, HST, Aalborg Universitet
Osteoarthritis in the knee is one of the most common pain conditions among the elderly population, and a heavy burden for both the patients and the healthcare system. Total knee replacement (TKR) is the only end-stage treatment known today. However, chronic postsurgical pain (CPSP) after TKR, a procedure conducted with the main purpose to relief the pain, occurs in one out of five TKR patients.
Despite the high number of TKR-surgeries performed all over the world little is known about how to prevent patients from developing chronic knee pain.
This PhD project consists of three studies. Study I focuses on 493 TKR patients five years after their 2011 TKR surgery of which 29% had developed CPSP. Study I shows that Fibromyalgia, Chronic pain conditions elsewhere in the body than the knee, or if the patient has previously had cancer significantly increased the risk of developing CPSP after TKR surgery.
Study II focuses on 80 of the 493 TKR patients in Study I. The 80 TKR patients received an additional medical examination to develop a profile of TKR patients with CPSP 5 years after their surgery. Study II shows that patients with CPSP have a significantly poorer outcome measured in terms of pain, function, and satisfaction. Furthermore, patients with CPSP had significantly higher levels of low-grade inflammation.
Study III examines if treatment with the muscle relaxant "Chlorzoxazone" in the first 7 days postoperative days can reduce the acute pain and thereby reduce the proportion of TKR patients with CPSP 1 year after surgery. Using a randomized placebo-controlled experiment with 200 patients, Study III found no significant differences in any parameters measured including pain, function, and adverse event in patients receiving “Chlorzoxazone” compared to those receiving placebo.
This PhD project can hopefully support decision makers and patients in their decision about TKR-surgery by providing knowledge about what comorbidities are important for the development of CPSP and showing that the presence of low-grade inflammation can be a driver in the patient’s development of CPSP. Furthermore, this PhD project indicates that “Chlorzoxazone” is not necessarily suitable for the treatment of acute postsurgical pain after TKR-surgery.
Department of Health Science and Technology, The Faulty of Medicine, Aalborg University
The Ph.D. Defense is organized as a hybrid event - digitally via Zoom and physical presence in room 4-107 Niels Jernes vej 14 , Aalborg Ø
25.10.2021 kl. 12.00