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Laboratory of Metabolism Modifying Medicine

Metabolism Modifying Medicine M3 Lab

Last modified: 26.06.2014

The Metabolism Modifying Medicine Lab is an international research group with scientists that have experience in fundamental basic research, clinical research as well as applied research with strong collaboration and connection to biotech and pharma industry.

Our research aims are to develop novel therapeutic approaches and drug candidates for diseases ranging from metabolic diseases, kidney diseases, liver diseases to auto-immune and brain diseases. A common theme is to try to understand the complex systemic alterations from molecules to integrated systems that arise from altered metabolism.

In one area we focus at aquaporin cell membrane water channels, which are crucial for water and solute balance in all known organisms. They are fundamental for water balance regulation in kidney, brain and other organs and in cardiovascular diseases including kidney diseases, heart failure, brain edema. The research area was highlighted by awarding Professor Peter Agre, Johns Hopkins University (a long-term close collaborator and adjuncted to the laboratory) the Nobel Prize in 2003 for the discovery of aquaporins.

In a 2nd research area we are investigating the role and importance of altered cellular lipid metabolism for development of life-threatening and debilitating brain diseases.  Carnitine Palmitoyl transferase CPT1, a mitochondrial membrane associated protein, plays a vital role  in cellular lipid metoblism and in development of a range of serious brain diseases, including multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis, depression and cancer.  The research have provided a paradigm shift in the fundamental understanding of various CNS diseases by showing enhanced, deranged lipid metabolism is a crucial step in the etiology of such brain diseases with a new fundamental and potent treatment potential.

In a 3rd area the focus is research on the interface of protein biophysics, biophotonics and molecular medicine. The goal is to modulate protein function and metabolic pathways with ligh. The continued work build on the discovery of a novel universal key mechanism triggered by UV light on proteins.

 

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Contact information

Head of Laboratory
John Dirk Nieland, Associate professor 
Laboratory of Metabolism Modifying Medicine
Dept. of Health Science and Technology
Aalborg University
Fredrik Bajers Vej 7E
DK-9220 Aalborg
Denmark
E-mail: jdn@hst.aau.dk
Phone: +45 9940 7548 / +45 2248 2276